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Folding@Home Information

Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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Active Members
Cancer News
Gene Variant For Biological Ageing In Humans Discovered
Keryx Biopharmaceuticals (NASDAQ: KERX) Responds To Erroneous Report About Planned Phase III Study For Patients With Colorectal Cancer
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More Smokers Than Non-Smokers Accept HPV Vaccination For Their Daughters
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Radiation Oncologists Push For Safety Standards
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Radiotherapy For Breast Cancer: A Lower Overall Dose Given In Fewer, Larger Doses Can Result In Better Quality Of Life
ArQule Announces Initiation Of Clinical Programs With ARQ 197 In Germ Cell Tumors And Colorectal Cancer
QIAGEN Unit And Pfizer Enter Into An Agreement To Develop A Companion Diagnostic For Brain Tumor Patients
New Agent To Manage Cancer Related Effusions
NVHR: Stop Liver Cancer 'Dead In Its Tracks' By Closing Funding Gap For Viral Hepatitis Education, Screening Programs
TGen Finalizes Alliance With Van Andel Research Institute
Feasible And Safe Treatment For Recurrent Hepatocellular Carcinoma In Elderly Patients
Kidney Cancer Drug Shows Promising Results
Protein That Splices And Dices Genes Identified By Scientists
Nuclear Pore Complexes Harbor New Class Of Gene Regulators
Progenics Presents Novel Multiplex PI3-Kinase Inhibitors At American Association For Cancer Research Conference On Protein Translation And Cancer
Panel Calls For Reducing Colorectal Cancer Deaths By Striking Down Barriers To Screening
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IGRT, SBRT Guidelines Issued By ASTRO, ACR
Delcath Systems Begins Data Analysis Of Phase III Trial
Developing A Cyberinfrastructure For Comparative Effectiveness In Cancer Research
The Institute Of Cancer Research Receives Environmental Honour
Older Female Cancer Survivors Have Added Health Issues Compared To Their Counterparts
Alzheimer's News
Age Concern And Help The Aged Comment On Dementia Research, UK
Dementia Costs UK More Than Cancer But Gets Less Research Funding, Report
Cigarette Smoking A Risk For Alzheimer's Disease According To Study
Alzheimer's Society Comment On Terry Pratchett's Richard Dimbleby Lecture, UK
Promising New Neuroimaging Techniques For Early Detection Of Alzheimer's Disease: Surprising New Tricks For Old Drugs
Researchers Image Earliest Signs Of Alzheimer's Before Symptoms Appear
Allon Initiates Trial To Expand Safety Profile For Dementia Drug Davunetide
Alzheimer's Society Comment On House Of Commons Dementia Debate, UK
Early Menopause Can Result In Earlier Onset Dementia
Alcohol Use And Cognitive Decline Among The Elderly
Geron Forms Collaboration To Investigate GRNOPC1 In Alzheimer's Disease Models
Alzheimer's Society Chief Executive Leaves For New Challenges
Lupin Receives US FDA Tentative Approval For Memantine HCl Tablets
Rush University Medical Center Leads Nationwide Clinical Trial Of Nutritional Drink For Alzheimer's
Discovery Of Stroke's 'Death Signal' May Aid Drug Development
Study Finds Unnecessary Mammograms Performed On Elderly Women With Dementia
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Discovery Of Compounds That Help Protect Nerve Cells
Single-Molecule, Real-Time Measurements Of A Key Biological Process
Treatment Of Alzheimer's Disease In Mice With Anti-Homocysteic Acid Antibody
Staring, Sleepiness, Other Mental Lapses More Likely In Patients With Alzheimer's
Drowsiness, Staring, And Other Mental Lapses May Signal Alzheimer's Disease
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Eye Test Could Aid Alzheimer's Detection
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Protein That Splices And Dices Genes Identified By Scientists
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[H]ard|Folding News Articles
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Institute Of Cancer Research Selects Supercomputer
King_N
[H]ard|Folding Administrator


Posts: 48
Points: 646,221
Work Units: 2,335

Posted: Thu Jan 28, 2010 12:54 am
SGI (NASDAQ: SGI), a global leader in HPC and data centre solutions, today announced that The Institute of Cancer Research (ICR) has selected SGI Altix UV, based on Intel Xeon processors (codenamed Nehalem-EX), to support its future life-saving research. The ICR joins the growing list of globally significant high performance computing (HPC) facilities embracing Altix UV as the future of open, high performance, big-memory supercomputing. Altix UV will provide the ICR with a massively scalable shared memory system to process its growing data requirements, including hundreds of terabytes of data for biological networks, MRI imaging, mass-spectrometry, phenotyping, genetics and deep-sequencing information across thousands of CPUs.

Full Story Here
[H] Christmas
King_N
[H]ard|Folding Administrator


Posts: 48
Points: 646,221
Work Units: 2,335

Posted: Wed Dec 23, 2009 11:13 pm
Not a whole lot to report this month, so I decided to share something that was posted on the forums in years long past.

I believe the author was relic, but I am not sure.

Quote:

Twas the Night Before a [H] Christmas

Twas the night before Christmas and all through the City
not a user was posting not even UncaMilty........

The cases were stacked by the hub with care,
in hopes that the Ti 500's soon would be there...

Frag2k was nestled all snug in his bed,
while visions of XP keychains danced in his head..

And Steve with his waterbox, and Kyle with his R.A.I.D.
had just settled down for a mid-Christmas upgrade...

When out on the forum there arose such a racket
Kyle grabbed his ban whip and prepared to crack it...

Away to the forums he flew like a flash
he eyed a new spammer and made his title Im on hash

Back to work Kyle went, his workbench lit by the monitor glow,
6 hours of testing and not a dang thing to show.....

Then what to Kyle's wondering eyes should appear?
none other than a Hooters girl and 8 frosty mugs of beer...

With a little tight rear, and next to nothing on,
Kyle knew in a moment it must be Sylvia St. John...

More rapid than SCSI his drink orders came,
as he whistled and hooted, and called them by name...

Gimme a Flat tire, a Guinness, a Miller and a Bud
A Michelob, a Coors, a Heineken and Shiner Bock is always good....

Three sheets to the wind he started overclocking his chips,
Until he installed the 4 in 1s and everything went to the pits....

As more and more XP chips ceased to function,
he threw them on the pile known as his keychain collection...

As the room filled with the smell of smoke and fried heatsink goo,
he passed out face down on his desk in a small pool of drool....

Several hours later stumbling through the den,
He had a revelation and ran looking for a conductive pen....

As he connected the L1's and ramped up the FSB,
he chuckled to himself with a maniacal glee....

He threw the bundled software in the bin marked trash
And said a silent prayer that maybe this one wouldn't crash...

His eyes how they sparkled! his expression how grim!
He downed another beer and hoped the drive would spin...

His motherboard was humming and starting to smoke,
He said to himself "oh crap, I think this ones gonna croak"....

He cursed the heat sink and gritted his teeth,
as the smoke curled around the chip like a wreath...

But wait he had one more XP sitting on a stray ratpad
He planned to clock this one higher, yes he was a bit mad....

This chip was under NDA but ready for action,
sent by AMD's PR department to get Kyle's reaction

With a flick of his pencil and a quick FSB bump,
he booted the system and felt a catch in his throat much like a lump....

He spoke not a word for fear it wouldn't work,
and when the system posted he stiffened with a jerk!

Clasping his hands in a silent prayer of thanks,
he thought the only thing better is Bin Laden on the business end of a tank

He installed 3D mark and Quake 3 too,
then went for a much needed run to the loo

The frame rates in Q3 were very impressive,
and he couldn't help but play a little excessive...

Fragging online some say is better than coke
but this weary overclocker said it was time for a smoke...

Jumping for joy and in bad need of a light,
He exclaimed "Merry Christmas to all and to all a good night!"


Merry Christmas and a Happy New Year to everyone.
New Cause for Alzheimer Disease
King_N
[H]ard|Folding Administrator


Posts: 48
Points: 646,221
Work Units: 2,335

Posted: Sat Nov 28, 2009 07:08 pm
Quote:
Dr. Carme Espinet and colleagues at the University of Lleida, Lleida, Spain have discovered that a precursor to nerve growth factor (pro-NGF) may play a pathogenic role in Alzheimer disease. They present these findings in the December 2009 issue of The American Journal of Pathology.


Full article here
New F@H Servers and GPU3
King_N
[H]ard|Folding Administrator


Posts: 48
Points: 646,221
Work Units: 2,335

Posted: Tue Oct 27, 2009 06:09 am
Stanford has ordered new servers to lighten the load.

Quote:

We've ordered a new class of servers which should make a big impact on FAH server load, and also allow us to release several new big projects with more WUs. We're very excited about this since we've been limited by server space recently, which has also lead to WU shortages. The new servers each have 24 x 2TB drives, so we should have plenty of space.


More Information here

Also some new core information.

Quote:

It will be called core_15 (the natural next number in the GPU series). The main changes there have been to incorporate the updated GPU code from OpenMM. OpenMM was based on our FAH GPU MD code to start, but has had several enhancements and additions.


More Information here
FAH work highlighted in Biomedical Computing Review
King_N
[H]ard|Folding Administrator


Posts: 48
Points: 646,221
Work Units: 2,335

Posted: Fri Sep 25, 2009 01:47 pm
The Biomedical Computing Review has an article on folding at home in the Fall 2009 issue.

Quote:
Two key parts of FAH technology -- OpenMM (the software that powers FAH on GPUs) and MSMbuilder (the algorithms that FAH uses to stitch together hundreds of thousands of donor simulations to get coherent results) are highlighted in this months Biomedical Computing Review.


It is available in PDF format and is located here.
  • Stickies: 0
  • News Articles: 103
  • Pages: 21
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