Links : [H]ard|Folding [H]ard|OCP
Local

Pacific

Mountain

Central

Eastern

GMT

[H] Member Login

Remember
NAVIGATION
[H]ard|Folding
Back to Main
Folding@Home
How To Join
Project Faqs
Project Add-ons
[H] Members
[H]orde Members
[H]ard|Farming
[H]ard|Folding Chat
[H]ard|Wallpaper
Statistics
F@H Statistics
[H] UD statistics
Unofficial
WCG Statistics
Contributors
[H]|Folding Council
Contributors

Powered by the [H]ard|OCP ServerPowered by PHP
Folding@Home Information

Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



How to Join | Project Faqs | Project Add-ons | Statistics | Download Client
New Members
[ 43 ]
 natecannon07/02/09 
 Zwit07/02/09 
 BioAngel07/02/09 
 PS3-CAHL07/02/09 
 Profit07/02/09 
 Kafir07/02/09 
 Killa_232707/02/09 
 AmnTex07/01/09 
 DocWolfe07/01/09 
 WillyN3D07/01/09 
 woodix07/01/09 
 vwgtir3207/01/09 
 Wyodiver07/01/09 
 markarr07/01/09 
 lynn.heinemann07/01/09 
 EdwardTheLess07/01/09 
 Pseudonymy06/30/09 
 bernstem06/30/09 
 n0jo406/30/09 
 hilliardsw5506/30/09 
 [H]06/30/09 
 saedrin06/29/09 
 Darkcloud06/29/09 
 Vividvoid06/29/09 
 Riiz06/29/09 
 ned707706/29/09 
 bzb06/29/09 
 Yossarian2206/29/09 
 chizwiz3206/29/09 
 Brzzk06/28/09 
 Emirikol06/28/09 
 lordmcfuzz06/28/09 
 bauhausRE06/28/09 
 Minidu06/28/09 
 Digital_Jedi_Rx06/28/09 
 Tadernutz06/28/09 
 J[H]06/26/09 
 DonDee06/26/09 
 Praeceps06/26/09 
 mryerse06/25/09 
 7Stars06/25/09 
 1madman06/25/09 
 darkimedes06/25/09 
Active Members
Cancer News
2009 Dr. Paul Janssen Award For Biomedical Research Won By Axel Ullrich
$500,000 Gruber Genetics Prize Awarded To Cancer Geneticist Janet Davison Rowley
Gefitinib Receives European Licence For The Treatment Of Lung Cancer For Patients With EGFR Activating Mutation Positive Tumours
New e-Science Service Could Accelerate Cancer Research
Cancer Survivors At Greater Risk Of Birth Complications; Special Monitoring Needed
BMA Reaffirms Opposition To Assisted Suicide, UK
Appeal For Cancer Patients To Trial New Nail Damage Remedy
Pfizer Discontinues Phase 3 Trial Of Sutent(R) In Metastatic Colorectal Cancer
Peregrine Awarded European Patent For Innovative Labeling Technology Featured In New Study In The Journal Of Nuclear Medicine
Advanced Prostate Cancer - New Review On PROSTVAC(TM) Published By Key Investigators From NCI
Colorectal Cancer - MDC Researchers Identify Genetic Markers For Metastasis Formation
Damon Runyon Cancer Research Foundation Awards $2.7M To 7 Top Young Clinical Investigators
Study Says High-Cost Cancer Drugs Have Little Benefit, Strain Health System
Re-Do Your Family Barbeque: Experts Offers Tips On Grilling To Reduce Cancer Risks
Vegetarians Have Lower Cancer Risk, UK Study
Extending The Shelf Life Of Antibody Drugs
Sutent Significantly Improved Progression-Free Survival For Patients With Advanced Pancreatic Islet Cell Tumours
Hunt For Blood Test To Determine Melanoma Survival Rates
Studying The Anti-Cancer Capabilities Of A Special Purple Sweet Potato
Gastrointestinal Endoscopy June Issue Study Highlights
Lance Armstrong Foundation And American Cancer Society Announce International Partnership To Fight Global Cancer Burden
New Biomarker Method Could Increase The Number Of Diagnostic Tests For Cancer
First Baby Is Born After A New Technique
Cancer Therapies: How Much Is Life Worth? The $440 Billion Question
New Ovarian Transplantation Technique Gives Greatly Improved Results In This Delicate Operation
Alzheimer's News
Alzheimer's Research Yields Potential Drug Target
Memory Decline In Mice Reversed By Blood Stem Cell Growth Factor
Eisai And Pfizer Decide Not To Appeal NICE Decision And Call For An Expedited Review Of Guidance For Alzheimer's Disease
Discovery Of Neural Stem Cell Differentiation Factor
Caregivers May Benefit From Adult Day Care
UK Dementia Research Funding Must Triple, Say Experts
Alzheimer's Society Puts Best Foot Forward With Dunwoody
Will Individuals With Alzheimer's Disease Benefit From Cataract Surgery?
Remembering What To Remember And What To Forget
Blood Flow In Alzheimer's Disease
New Mechanism For Amyloid Beta Protein's Toxic Impact On The Alzheimer's Brain
Alzheimer's Society Comment On Annual Survey Of UK Local Authority Baseline Fee Rates 2009/10
Statins Can Protect Against Alzheimer's Disease, According To New Study
Cerebrospinal Fluid Shows Alzheimer's Disease Deterioration Much Earlier
Statins Can Protect Against Alzheimer's Disease, According To New Study
Alzheimer, Headache & Co.: Detecting Neurological Illnesses Better And Earlier
Memory Impairment Predicts Alzheimer's Disease
Welsh Assembly Government Opens Up Debate On Dementia, Wales
NIH Resources Grant Extended For The National Resource For Aplysia
New Data Demonstrate Potential For Early Detection Of Alzheimer's Disease Using New Diagnostic Technology, Which Could Lead To Improved Treatment
Another McGill/JGH Breakthrough Opens Door To Early Alzheimer's Diagnosis
Outstanding Canadians Tireless In Their Efforts To Help Those Living With Dementia
Social Care Workforce Not Ready To Deliver Dementia Care - MPs
Measuring Brain's Memory Centers May Help Predict Alzheimer's
ExonHit Announces Last Patient Out For EHT 0202 Phase IIa Study In Alzheimer's
Biochemistry News
Alzheimer's Research Yields Potential Drug Target
Longevity Of Dental Fillings May Be Increased By Nanotechnology
2009 Dr. Paul Janssen Award For Biomedical Research Won By Axel Ullrich
$500,000 Gruber Neuroscience Prize Awarded To Hall, Rosbash And Young
Targeting Human And Animal Diseases In Africa: Research Network Wins Approximately £5.7 Million
Brittle Table Salt Can Stretch Like Taffy In The Nanoworld - Nano Letters
New e-Science Service Could Accelerate Cancer Research
Microbial Analysis, Micropatterning Methods Featured In Cold Spring Harbor Protocols
Biological 'Fountain Of Youth' Discovered In New World Bat Caves
Echo-Location In Humans Developed By Spanish Scientists
Mechanics Of Bacteria Colonies Measured By New Lab-On-A-Chip
Innovative Technology Shatters The Barriers Of Modern Light Microscopy
Bio-Inspired Cilia Mix Medical Reagents At Small Scales
Forest Biotechnology Obstructed By Anti-Biotech Groups
Secrets Of Scorpion Venom Revealed By Genetic Analysis
Toxic Chemicals Affect Steroid Hormones Differently In Humans And Invertebrates
Key Culprits In Lupus Revealed By Scripps Research Scientists
How The Body Adapts To Exercise At Altitude And How Hypoxia Affects Muscle And Nerve Responses
'Awakenings' That Occur With Popular Sleep-Aid Ambien May Be Explained By GUMC Study
Intestinal Cells Surprisingly Active In Pursuit Of Nutrition And Defense
Female Human Embryos Adjust The Balance Of X Chromosomes Before Implantation
Isotopes, The Atomic Clues Used To Solve Crimes, Date Ancient Artifacts And Identify Chemicals
News From The American Chemical Society, June 24, 2009
Running Faster On High-Grade Oil: Mouse Study
Newsweek, Boston Globe Examine Ways To Combat Mosquito-Borne Illness
[H]ard|Folding News Articles
  • Stickies: 0
  • News Articles: 96
  • Pages: 20
Scientists Discover Protein That Stops Cancer Spread
King_N
[H]ard|Folding Administrator


Posts: 41
Points: 505,302
Work Units: 2,083
Status: Active
Posted: Fri Jun 26, 2009 06:05 am
Quote:
Scientists in the US have discovered that cancer tumors that don't spread to other parts of the body secrete a protein called prosaposin and that metastatic tumors, which do spread, don't secrete much of it. They suggest this discovery could lead the way to developing new treatments that stop cancers from spreading.


Full article here

Site function updates in progress
King_N
[H]ard|Folding Administrator


Posts: 41
Points: 505,302
Work Units: 2,083
Status: Active
Posted: Tue May 19, 2009 04:33 am
Over the last few weeks I have been working on updating functions across the site.

These upgrades are behind the scene type upgrades which means that the layout itself is not being changed, rather the code that makes everything else work is being changed to upgrade performance, these changes will continue throughout the next few months.

While I'm in the process of changing the code you may stumble upon a page that doesn't load all the way or can not be found, while this should be a very rare occurance it just means you chose a page in the process of being updated, simply wait a few and hit refresh to fix the issue.
Nanoparticles Track Cancer Cell Changes
King_N
[H]ard|Folding Administrator


Posts: 41
Points: 505,302
Work Units: 2,083
Status: Active
Posted: Fri Apr 17, 2009 11:30 am
Stanford Researchers have harnessed nanoparticles to track cancer-cell Changes.

Quote:

The more dots there are, the more accurate a picture you get when you connect them. A new imaging technology could give scientists the ability to simultaneously measure as many as 100 or more distinct features in or on a single cell. In a disease such as cancer, that capability would provide a much better picture of what's going on in individual tumor cells.


Full article is located here.
Alzheimers Genome Biomarker Data
King_N
[H]ard|Folding Administrator


Posts: 41
Points: 505,302
Work Units: 2,083
Status: Active
Posted: Mon Mar 23, 2009 02:50 am
The Foundation for the National Institutes of Health has released it's Alzheimer's Genome Biomarker Data to the scientific community.

Quote:

The Foundation for the National Institutes of Health, the convener of a $60 million public-private partnership begun by the National Institute on Aging (NIA), and supported by the NIH and the FDA along with more than 20 private-sector companies and organizations, announces the availability of genome biomarker data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) for scientists world-wide for further analysis. This ongoing, 6-year ADNI study is the most comprehensive effort focused on identifying brain and other biological changes associated with memory decline, and provides the most extensive and robust dataset of its kind related to Alzheimer's.The Foundation for the National Institutes of Health, the convener of a $60 million public-private partnership begun by the National Institute on Aging (NIA), and supported by the NIH and the FDA along with more than 20 private-sector companies and organizations, announces the availability of genome biomarker data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) for scientists world-wide for further analysis. This ongoing, 6-year ADNI study is the most comprehensive effort focused on identifying brain and other biological changes associated with memory decline, and provides the most extensive and robust dataset of its kind related to Alzheimer's.


Full article is located here.
New F@H paper released
King_N
[H]ard|Folding Administrator


Posts: 41
Points: 505,302
Work Units: 2,083
Status: Active
Posted: Tue Feb 17, 2009 07:01 pm
Stanford has released a new paper and it was accepted today.

Quote:


The Predicted Structure of the Headpiece of the Huntingtin Protein and Its Implications on Huntingtin Aggregation

We have performed simulated tempering molecular dynamics simulations to study the thermodynamics of the headpiece of the Huntingtin (Htt) protein (N17Htt). With converged sampling, we found this peptide is highly helical, as previously proposed. Interestingly, this peptide is also found to adopt two different and seemingly stable states. The region from residue 4 (L) to residue 9 (K) has a strong helicity from our simulations, which is supported by experimental studies. However, contrary to what was initially proposed, we have found that simulations predict the most populated state as a two-helix bundle rather than a single straight helix, although a significant percentage of structures do still adopt a single linear helix. The fact that Htt aggregation is nucleation dependent infers the importance of a critical transition. It has been shown that N17Htt is involved in this rate-limiting step. In this study, we propose two possible mechanisms for this nucleating event stemming from the transition between two-helix bundle state and single-helix state for N17Htt and the experimentally observed interactions between the N17Htt and polyQ domains. More strikingly, an extensive hydrophobic surface area is found to be exposed to solvent in the dominant monomeric state of N17Htt. We propose the most fundamental role played by N17Htt would be initializing the dimerization and pulling the polyQ chains into adequate spatial proximity for the nucleation event to proceed.


Full article is located here.

Also it seems like the database had some problems again with one of the tables, I gave it a good swift kick (just kidding). I fixed the issue and everything seems to be back to normal again.
  • Stickies: 0
  • News Articles: 96
  • Pages: 20
Who's Online
Administrator Council News Member
[H]ard|Folding Copyright © 2001 - 2009 by King_N,   [H]ard|OCP Copyright © 1998 - 2009 by Kyle Bennett

All trademarks used are properties of their respective owners. All rights reserved.